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KMID : 0381120080300010083
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Genes and Genomics
2008 Volume.30 No. 1 p.83 ~ p.90
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Temporal Regulation of Distalless Expression by Mutations in BX-C and Polycomb genes
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Jung Keuk-Il
Kim Sang-Hee
Jeon Sang-Hak
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Abstract
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Homeotic genes are responsible for the specification of segment identity during embryonic development. The homeotic genes of Drosophila are clustered in the Antennapedia complex (ANT-C) and bithorax complex (BX-C). The expression of Distalless (Dll) is initiated from late stage 10 in the thoracic limb primordia and it is specifically required for limb development in the Drosophila embryo. In this study we investigated the temporal regulation of Dll expression in the thoracic segments. Dll expression was expanded to the abdominal region in the loss-of-function mutation of the Ubx, abdA or AbdB gene. When Ubx, abdA or AbdB was ectopically expressed in the thorax using the GAL4/UAS system, Dll expression was not observed in the thorax. However, when the BX-C genes were ectopically expressed at stage 11 of Polycomb mutant embryo, the repression of Dll expression by the ectopic homeotic gene products was restricted to the third thoracic segment. This result suggested that Dll expression pattern was determined at embryonic stage 11 and that the ectopic expression of BX-C genes after stage 11 did not affect Dll expression.
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KEYWORD
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homeotic genes, Distalless, Polycomb, Drosophila melanogaster
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